The Growing Importance of Nucleic Acid Stability
Stability is a critical factor in the success of nucleic acid-based therapies. Without sufficient stability, DNA, RNA, and synthetic oligonucleotides degrade rapidly, losing therapeutic potential.
Scientists use various chemical modifications to enhance durability. For RNA therapies, changes to the backbone or sugar structures help resist enzymatic breakdown. Lipid nanoparticles further protect nucleic acids during transport.
Environmental factors such as temperature, pH, and storage conditions also impact stability. Careful formulation ensures that therapeutic molecules remain viable until they reach target cells.
Continued progress in stabilization techniques is essential for expanding the applicability of nucleic acid therapeutics, especially in fields where long-term delivery is required.